Systems, methods, and compositions for achieving closure of vascular puncture sites
US6830756B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Feb 9, 2001 |
| Grant date | Dec 14, 2004 |
| Priority date | — |
| Expiry date | Feb 9, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2017/0065
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Systems, methods, and compositions achieve rapid closure of vascular puncture sites. The systems and methods form a vascular closure composition by mixing together a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material having a functionality of at least three. The second component includes a nucleophilic material that, when mixed with the first component within a reaction pH range of between 7 to 9, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material has a pH within the reaction pH range. The systems and methods apply the composition to seal a vascular puncture site.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.