Compounds and methods for modulating claudin-mediated functions
US6830894B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 3, 1999 |
| Grant date | Dec 14, 2004 |
| Priority date | — |
| Expiry date | Nov 3, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for using modulating agents to enhance or inhibit claudin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase blood/brain barrier permeability. The modulating agents comprise at least one claudin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the claudin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.