Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity

US6831084B1 · kind B1 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Wayne E. Childers · New Hope, US
• Horace Fletcher, III · Pottstown, US
• Magid A. Abou-Gharbia · Wilmington, US
• John P. Yardley · King of Prussia, US

Key dates

• Filing date: Nov 6, 2000
• Grant date: Dec 14, 2004
• Expiry date: Sep 5, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/496
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, AIDS dementia, retinal disease, diabetic peripheral neuropathy, multiple sclerosis, stroke, acute thromboembolic stroke, focal ischemia, global ischemia, transient ischemic attack, ischemia resulting from surgery, head trauma, spinal trauma, hypoxia, fetal hypoxia, and neuroprotection, the compounds having the structure: wherein X is —CH2— or a bond; Y is —(CH2)m— or —(CH2)—O—(CH2)—; m 0 or 1; n is 0 or 1; R1 and R2 are independently selected from optionally substituted aryl or heteroaryl; the optical isomers and the pharmaceutically acceptable salts thereof.