Cephalotaxane derivatives and process for their preparation
US6831180B1 · kind B1 · utility
6Cited by
25References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 16, 1999 |
| Grant date | Dec 14, 2004 |
| Priority date | — |
| Expiry date | Mar 16, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D453/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloids used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.