Lipoxin A4 analogs

US6831186B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• John G. Bauman · El Sobrante, US
• William Guilford · San Leandro, US
• John Parkinson · Martinez, US
• Werner Skuballa · Berlin, DE
• Babu Subramanyam · Benicia, US

Key dates

• Filing date: Oct 22, 2002
• Grant date: Dec 14, 2004
• Expiry date: Oct 22, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.