Urokinase inhibitors

US6831196B2 · kind B2 · utility

Assignee

• Curacyte AG · DE

Inventors

• Jörg Stürzebecher · Erfurt, DE
• Torsten Steinmetzer · Jena, DE
• Andrea Schweinitz · Jena, DE

Key dates

• Filing date: Dec 9, 2002
• Grant date: Dec 14, 2004
• Expiry date: Jan 21, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a highly active, highly specific urokinase inhibitor which is suitable for therapeutic applications and can be synthesized in an extremely simple manner. Surprisingly, it was found that amidino benzylamine derivatives, especially 4-amidino-benzylamine, with two bonded amino acids represent a new group of highly active and very selective uPA inhibitors. The urokinase inhibitors can be used in medical applications, e.g. in the treatment of malign tumors such as in cases of metastatic spread.