Polypeptide having amidolytic activity for a serpin
US6833262B1 · kind B1 · utility
8Cited by
1References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 19, 2001 |
| Grant date | Dec 21, 2004 |
| Priority date | — |
| Expiry date | Oct 19, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An isolated oral bacterial polypeptide having amidolytic activity for cleavage of denatured polypeptides and nondenatured serpin polypeptides and particularly a human &agr;1-proteinase inhibitor polypeptide is provided. The mature polypeptide of the invention has a molecular weight of about 70 kD to about 80 kD. Also provided is an isolated nucleic acid sequence encoding the oral bacterial polypeptide of the invention, methods for identifying inhibitors of the polypeptide and compositions such as immunogenic compositions and inhibitor compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.