Compositions and methods for generating chimeric heteromultimers
US6833441B2 · kind B2 · utility
83Cited by
49References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 1, 2001 |
| Grant date | Dec 21, 2004 |
| Priority date | — |
| Expiry date | Nov 10, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.