Expression of the toxic portion of Cry1A in plants
US6833449B1 · kind B1 · utility
10Cited by
5References
3Claims
0Family size
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Key dates
| Filing date | Mar 21, 2003 |
| Grant date | Dec 21, 2004 |
| Priority date | — |
| Expiry date | Jul 11, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A40/146
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed is a method for improving the expression of Cry1A in plants that makes use of codons preferentially used in native plant genes. The coding sequence of the gene for the Bacillus thuringiensis delta endotoxin Cry1A crystal protein was analyzed and found to have codons not preferred by plants. By constructing a synthetic protein coding sequence that uses codons which are preferred in plant genes, expression of the protein in plant cells was improved.
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