Phosphite ester oxidation in nucleic acid array preparation
US6833450B1 · kind B1 · utility
95Cited by
43References
18Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 15, 2001 |
| Grant date | Dec 21, 2004 |
| Priority date | — |
| Expiry date | Mar 15, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/809
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods are provided for preparing nucleic acid arrays on a support. In these methods a plurality of nucleic acids are synthesized on the support and the synthesis steps include oxidizing a phosphite triester nucleic acid linkage to a phosphate triester nucleic acid linkage using a solution about 0.005 to about 0.05 M iodine in a mixture comprising water and organic solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.