Lipopolysaccharides (LPS) extracted from Escherichia coli

US6833451B2 · kind B2 · utility

Assignee

• Pharma-Zentrale GmbH · DE

Inventors

• Hans Proppert · Hagen, DE
• Jürgen Malinka · Selm, DE
• Jürgen Schulze · Michendorf, DE
• Ulrich Sonnenborn · Bochum, DE
• Ulrich Zähringer · Kellinghusen, DE
• Artur J. Ulmer · Nienwohld, DE
• Ernst Theodor RIETSCHEL · Hamburg, DE

Key dates

• Filing date: Dec 23, 2002
• Grant date: Dec 21, 2004
• Expiry date: Sep 6, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Lipopolysaccharides and processes for producting the lipopolysaccharides are provided. The lipopolysaccharide has a lipid A portion, a core oligosaccharide portion, and an O-specific chain having a single repeating unit 06. A lipopolysaccharide may be produced by washing and drying and E. coli bacterial mass, subjecting the washed and dried bacterial mass to a phenol/water extraction, and treating the extract with RNases, DNases, and proteinase K.