Optical-chemical sensor

US6835351B2 · kind B2 · utility

Assignee

• F. Hoffmann-La Roche AG · CH

Inventors

• Christian Huber · Zwingenberg, DE
• Tobias Werner · Regensburg, DE
• Otto S. Wolfbeis · Regensburg, DE
• Douglas E. Bell · Coral Springs, US
• Susannah Young · Norcross, US

Key dates

• Filing date: Jan 2, 2003
• Grant date: Dec 28, 2004
• Expiry date: Jan 2, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/193333
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An optical-chemical sensor which is suitable for the continuous and discontinuous determination by luminescence optics of the concentration of chloride in an aqueous sample and which comprises a luminescence indicator (I) and a polymer (H) carrying the luminescence indicator (I) is characterized in that the luminescence indicator (I) is a non-lipophile acridine or bisacridine compound and the polymer (H) is a linear-chain hydrophile polymer soluble in an organic solvent, whereby it is possible to excite the sensor by commercially available LEDs, to manufacture very large numbers thereof at a moderate cost and in a reproducible way and, preferably, to use it for the determination of physiological chloride concentrations and the sensor furthermore has a wide dynamic measuring range for the determination of chloride; a high sensitivity, stability and reproducibility; a high selectivity for chloride; and a low pH cross-sensitivity.