Preparation of submicron sized nanoparticles via dispersion lyophilization

US6835396B2 · kind B2 · utility

Assignee

• Baxter International Inc. · US

Inventors

• Sean Brynjelsen · Lake in the Hills, US
• Mark Doty · Grayslake, US
• James Kipp · Wauconda, US
• Nailesh Jayswal · Bensenville, US
• Krishnaswamy Narayanan · Waukesha, US

Key dates

• Filing date: Jun 26, 2002
• Grant date: Dec 28, 2004
• Expiry date: Jun 11, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5192
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having the poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.