Patent · US Expired

Phenylalanine enamide derivatives

US6835738B1 · kind B1 · utility

7Cited by

0References

6Claims

0Family size

Assignee

Celltech R&D Limited · GB

Inventors

Julien Alistair Brown · Slough, GB
Stuart Bailey · Leatherhead, GB
Stephen Brand · Dundee, GB

Key dates

Filing date	Jul 16, 2003
Grant date	Dec 28, 2004
Priority date	—
Expiry date	Jul 16, 2023

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a —CH(CH3)2, —(CH2)2CH3, —CH2C(CH3)3, —CH2CH2OH, —CH2CH2OCH3, —CH2CH2OCH2CH2OH, —CH2CH2OCH2CH2OCH3, group; and the salts, solvates and N-oxides thereof.Compounds according to the invention are potent and selective inhibitors of &agr;4 integrins. The compounds are of use in modulating cell adhesion and in particular are of use in the prophylaxis and treatment of diseases or disorders including inflammation in which the extravasation of leukocytes plays a role and the invention extends to such a use and to the use of the compounds for the manufacture of a medicament for treating such diseases or disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.