Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties

US6835802B2 · kind B2 · utility

Assignee

• Nobex Corporation · US

Inventors

• Nnochiri Ekwuribe · Cary, US
• Christopher H. Price · Chapel Hill, US
• Aslam M. Ansari · Rockville, US
• Amy L. Odenbaugh · Morrisville, US

Key dates

• Filing date: Jun 4, 2001
• Grant date: Dec 28, 2004
• Expiry date: Dec 20, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08L71/02
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

Methods of synthesizing a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties include:reacting a substantially monodispersed mixture of compounds having the structure of Formula I:R1(OC2H4)n—O−X+  (I)wherein R1 is H or a lipophilic moiety; n is from 1 to 25; and X+ is a positive ion, with a substantially monodispersed mixture of compounds having the structure of Formula II:R2(OC2H4)m—OMs  (II)wherein R2 is H or a lipophilic moiety; and m is from 1 to 25, under conditions sufficient to provide a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties and having the structure of Formula III:R2(OC2H4)m+n—OR1  (III).