Oligonucleotide N3′→P5′ Thiophosphoramidates: their synthesis and use
US6835826B2 · kind B2 · utility
30Cited by
25References
2Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 17, 2003 |
| Grant date | Dec 28, 2004 |
| Priority date | — |
| Expiry date | Jun 29, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S−)O-5′ linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3′→P5′ phosphoramidates and to exhibit a much higher acid stability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.