Method for the production of biperiden II

US6835839B2 · kind B2 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Peter Klein · Itzehoe, DE
• Marco Thyes
• Markus Grosse · Schwetzingen, DE
• Klaus Weber · Ludwigshafen, DE
• Elmar Vilsmaier · Otterbach, DE

Key dates

• Filing date: Apr 5, 2004
• Grant date: Dec 28, 2004
• Expiry date: Apr 5, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/088
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo[2.2.1.]hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound, wherein the exo/endo ratio of 1-(bicylo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is at least 4.5:1.