Process for synthesizing N-(mercaptoacyl) amino acid derivatives from alpha-substituted acrylic acids
US6835851B2 · kind B2 · utility
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6References
17Claims
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Inventors
Key dates
| Filing date | Nov 9, 2001 |
| Grant date | Dec 28, 2004 |
| Priority date | — |
| Expiry date | Mar 8, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C327/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The instant invention relates to a process for preparing a compound of formula (I): said process comprising a step (B) which consists in performing a Michael addition of a thioacid RS4H on to an &agr;-substituted acrylamide derivative.The invention also relates to the enantioselective synthesis of compounds of formula (I) wherein R2 is other than H, in the preferential (S, S) configuration:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.