Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
US6835853B2 · kind B2 · utility
2Cited by
4References
38Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 31, 2002 |
| Grant date | Dec 28, 2004 |
| Priority date | — |
| Expiry date | Jul 31, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.