Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene

US6835857B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Oliver Meyer · Ingelheim am Rhein, DE
• Helmut Heitger · Ingelheim am Rhein, DE

Key dates

• Filing date: Mar 4, 2003
• Grant date: Dec 28, 2004
• Expiry date: Mar 4, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C41/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to an improved process for preparing 4-(6-bromohexyloxy)-butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst, wherein 4-phenylbutanol in a diluent is metered into a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst and a diluent, and the use of the 4-(6-bromohexyloxy)-butylbenzene thus prepared for producing salmeterol in a method known per se.