Biopolymer array substrate thickness dependent automated focus-distance determination method for biopolymer array scanners
US6835938B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 31, 2002 |
| Grant date | Dec 28, 2004 |
| Priority date | — |
| Expiry date | Feb 12, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/276
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and system for determining a biopolymer array substrate thickness dependent optimal focus distance for scanning a molecular array by a molecular array scanner are disclosed. Also disclosed are methods of determining the thickness of a biopolymer array substrate using a position sensitive device (PSD) component of a biopolymer array scanner. Further methods include determining the thickness of said biopolymeric array and automatically selecting an optimal focus distance using the determined thickness and a calibration function on thickness versus optimal focus distance. The subject invention finds use in a variety of different applications, including both genomic and proteomic applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.