2,4-Di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineaoplastic agents
US6838464B2 · kind B2 · utility
118Cited by
7References
14Claims
0Family size
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Key dates
| Filing date | Feb 26, 2001 |
| Grant date | Jan 4, 2005 |
| Priority date | — |
| Expiry date | Feb 26, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Pyrimidine derivatives of formula (I) wherein Q1, Q2, G and R1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine/threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.