Patent · US Expired

Human pluripotent hematopoietic colony stimulating factor, method of production and use

US6838549B2 · kind B2 · utility

1Cited by

5References

1Claims

0Family size

Assignee

Sloan Kettering Institute for Cancer Research · US

Inventors

Karl Welte · New York, US
Erich Platzer · Erlangen, DE
Janice L. Gabrilove · New York, US
Roland Mertelsmann · Chappaqua, US
Malcolm A. S. Moore · New York, US

Key dates

Filing date	Apr 4, 2002
Grant date	Jan 4, 2005
Priority date	—
Expiry date	Sep 9, 2022

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5×108 U/mg protein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.