Method for decreasing low density lipoprotein

US6841547B2 · kind B2 · utility

Assignees

• ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY · US
• Montefiore Medical Center · US
• The Research Foundation of the State University of New York · US

Inventors

• David Brown · Yorba Linda, US
• Lorne M. Golub · Smithtown, US
• Hsi-Ming Lee · Setauket, US
• Robert A. Greenwald · Melville, US
• Maria Ryan · Port Jefferson Station, US
• Kavita Desai · The Bronx, US

Key dates

• Filing date: Feb 28, 2003
• Grant date: Jan 11, 2005
• Expiry date: Mar 14, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/65
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for decreasing elevated serum/plasma LDL-cholesterol levels or LDL-cholesterol levels and CRP levels in a mammal in need thereof. The methods comprises administering an effective amount of a tetracycline formulation. In one embodiment, the tetracycline formulation is a non-antibacterial tetracycline. In another embodiment, the tetracycline formulation is an antibacterial tetracycline at a sub-antibacterial amount.