Piperazine-based nucleic acid analogs

US6841675B1 · kind B1 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Jurgen Schmidt · Los Alamos, US
• Louis A. Silks · Los Alamos, US
• Ryszard Michalczyk · Los Alamos, US

Key dates

• Filing date: Jun 13, 2002
• Grant date: Jan 11, 2005
• Expiry date: Jun 13, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.