Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix

US6844010B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Jean A. Setterstrom · Silver Spring, US
• John E. Van Hamont · Clarence, US
• Robert H. Reid · Kensington, US
• Elliot Jacob · Silver Spring, US
• Ramasubbu Jeyanthi · Columbia, US
• Edgar C. Boedeker · Bethesda, US
• Charles E. McQueen · Olney, US
• Daniel L. Jarboe · Silver Spring, US
• Frederick J. Cassels · Gaithersburg, US
• William R. Brown · Denver, US
• Curt Thies · Ballwin, US
• Thomas R. Tice · York, US
• F. Donald Roberts · Dover, US
• Phil Friden · Bedford, US

Key dates

• Filing date: Jul 18, 2000
• Grant date: Jan 18, 2005
• Expiry date: Jul 18, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.