Functional surface coating

US6844028B2 · kind B2 · utility

Assignee

• Accelr8 Technology Corporation · US

Inventors

• Guoqiano Mao · Smyrna, US
• Steven W. Metzger · Westminster, US
• Michael J. Lochhead · Boulder, US

Key dates

• Filing date: Jun 25, 2002
• Grant date: Jan 18, 2005
• Expiry date: Jun 25, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/31678
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.