Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US6844148B1 · kind B1 · utility
15Cited by
25References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 22, 2000 |
| Grant date | Jan 18, 2005 |
| Priority date | — |
| Expiry date | Sep 22, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96472
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cleaves the α-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.