Oligomerization of hepatitis delta antigen

US6844171B1 · kind B1 · utility

Assignee

• President and Fellows of Harvard College · US

Inventors

• James Hogle · Newton, US
• Harmon Zuccola · Westwood, US
• David Filman · Waltham, US
• Carl Elkin · Arlington, US

Key dates

• Filing date: Jul 1, 1999
• Grant date: Jan 18, 2005
• Expiry date: Jul 1, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/10122
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This invention relates to HDAg peptides, including mutants, derivatives fragments and fusion molecules, including fusion proteins, coiled-coil oligomers, nucleic acid molecules, vectors comprising HDAg nucleic acid molecules, cells comprising said molecules, methods of multivalent expression and association of binding moieties of HDAg fusion molecules, and methods of use involving the molecules.The molecules are particularly useful as a framework for multivalent display via formation of C-terminal and/or N-terminal fusion proteins or via chemical coupling to chemically reactive sidechains, e.g. cysteine residues.