Water-soluble, chlorhexidine-containing compositions and use thereof

US6844306B2 · kind B2 · utility

Assignee

• Degussa AG · DE

Inventors

• Peter Werle · Gelnhausen, DE
• Friedhelm Merz · Nierstein, DE
• Jolanta Habrich · Großkrotzenburg, DE

Key dates

• Filing date: Oct 19, 2001
• Grant date: Jan 18, 2005
• Expiry date: Jul 19, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/00
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to water-soluble, chlorhexidine-containing compositions having a long shelf life. The compositions are in the form of powder, granules or tablets and consist substantially of (i) a salt of chlorhexidine with 2 moles of a sugar acid and a microbicidally active quaternary ammonium bromide, or of (ii) chlorhexidine, a sugar acid or sugar lactone, with at least 2 moles of sugar acid or sugar lactone being present per mole of chlorhexidine, and a microbicidally active quaternary ammonium bromide. Peferred compositions consist substantially of chlorhexidine digluconate and N-cetyl-N,N,N-trimethylammonium bromide (cetrimide) in a weight ratio of 1:1 to 1:10. The solid compositions are stable, with little or no p-chloroaniline splitting off during storage.