Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use
US6844318B2 · kind B2 · utility
10Cited by
6References
37Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 15, 2001 |
| Grant date | Jan 18, 2005 |
| Priority date | — |
| Expiry date | Mar 15, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to antineoplastic agents conjugated to enzyme-cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and to the use of such conjugated compounds as chemotherapeutic agents in the targeted treatment of cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.