N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent

US6844343B1 · kind B1 · utility

Assignee

• Vasopharm Biotech GmbH · DE

Inventors

• Wolfgang Pfleiderer · Konstanz, DE
• Harald Schmidt · Wallisellen, CH
• Lothar Fröhlich · Coburg, DE
• Peter F. Kotsonis · Orlando, US
• Shahriyar Taghavi-Moghadam · Neu-Isenburg, DE

Key dates

• Filing date: Sep 11, 2000
• Grant date: Jan 18, 2005
• Expiry date: Sep 11, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I), where preferably: A=a bridge of partial formula (II) or (III), R1 and R2=independently (substituted) alkyl, aryl or aralkyl, or together form a heterocycle, R3=H, —CO-Alkyl, or —CO-Aryl, R4=Aryl, —CO—O-Aryl or —CO-Aryl and R5=H, are potent inhibitors of NO-synthase and are suitable as pharmaceutical agents of prophylaxis and treatment of disease states associates with a disturbed NO metabolism.