Chromogenic substrates of sialidase and methods of making and using the same
US6844346B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 24, 2002 |
| Grant date | Jan 18, 2005 |
| Priority date | — |
| Expiry date | Dec 24, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/075
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-acetylneuraminic acid glycosides. In particular, this invention provides a novel class of these compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.