Methods and molecules useful for identifying molecules that bind LFA-1 and for determining receptor occupancy
US6846643B2 · kind B2 · utility
1Cited by
0References
9Claims
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Assignee
Inventors
Key dates
| Filing date | Aug 6, 2001 |
| Grant date | Jan 25, 2005 |
| Priority date | — |
| Expiry date | Sep 21, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates generally to a method for identifying molecules that bind the R7.1 epitope of LFA-1 or bind LFA-1 such that the R7.1 epitope is modified. The present invention further relates to a method for determining occupancy of the LFA-1 receptor by molecules that bind to the R7.1 epitope or bind LFA-1 such that the R7.1 epitope is modified after administration to a subject. The present invention further relates to molecules useful in the methods of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.