Enhanced secretion of a polypeptide by a microorganism
US6846653B2 · kind B2 · utility
10Cited by
2References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 9, 2001 |
| Grant date | Jan 25, 2005 |
| Priority date | — |
| Expiry date | Mar 5, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/95
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of charged amino acid residues at the carboxy terminus either by adding to the native peptide or by replacing, i.e., substituting, the terminal residues of the native peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.