Skin substitutes and uses thereof
US6846675B2 · kind B2 · utility
26Cited by
12References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 1, 2002 |
| Grant date | Jan 25, 2005 |
| Priority date | — |
| Expiry date | Mar 1, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to in vitro cultured skin substitutes, and in particular to improved methods for organotypic culture of skin substitutes. In some embodiments, the dermal equivalent of the skin substitute is lifted to air interface of the culture prior to seeding with keratinocytes. In other embodiments, increased concentrations of collagen are used to form the dermal equivalent. In still other embodiments, optimized media are utilized to maintain the skin equivalents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.