Substituted N-(indole-2-carbonyl) -amides and derivatives as glycogen phosphorylase inhibitors

US6846820B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Dennis J. Hoover · Stonington, US
• Bernard Hulin · Essex, US
• William H. Martin · Holmdel, US
• Judith Treadway · Gales Ferry, US

Key dates

• Filing date: Jun 17, 2003
• Grant date: Jan 25, 2005
• Expiry date: Jun 17, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to certain indole-2-carboxamides of formula (I) and the pharmaceutically acceptable salts and prodrugs thereof, wherein R6 is carboxy, (C1-C8)alkoxycarbonyl, C(O)NR8R9 or C(O)R12, useful as inhibitors of glycogen phosphorylase, methods of treating glycogen phosphorylase dependent diseases or conditions with such compounds and pharmaceutical compositions comprising such compounds.