Crude extract from Viscum album coloratum, and proteins and lectins isolated therefrom
US6846913B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 27, 2000 |
| Grant date | Jan 25, 2005 |
| Priority date | — |
| Expiry date | Jun 24, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is an extract from Korean mistletoe KM-110, which is of immunity enhancement and activity against tumor metastasis and can be used as an adjuvant material for vaccines applicable for the induction of humoral and cell-mediated immunity. Also disclosed are its fractions, a protein fraction KM-AS, a lectin fraction KML-C, lectin components KML-IIU and KML-IIL, which both are further purified from lectin fraction KML-C, a protein KMHBP which is obtained through heparin binding chromatography eluting with NaCl from a fraction C-free AS which is a portion of the KM-AS free of KML-C, and a mixture KM of the KMHBP and the KML-C. They are revealed as to their roles in the humoral and cell-mediated immunity enhancement and antitumoral activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.