Methods and compositions for enhancing cartilage repair

US6849255B2 · kind B2 · utility

Assignees

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL
• Gesellschaft fur Biotechnologische Forschung mbH (GBF) · DE

Inventors

• Dan Gazit · Modiin-Maccabim-Reut, IL
• Yoram Zilberman · Jerusalem, IL
• Gadi Turgeman · Jerusalem, IL
• Gadi Pelled · Los Angeles, US
• Gerhard Gross · Bocholt, DE
• Stefan Czichos · Peine, DE
• Andrea Hoffmann · Hannover, DE

Key dates

• Filing date: Feb 8, 2002
• Grant date: Feb 1, 2005
• Expiry date: Nov 5, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.