Patent · US Expired

Methods of optimizing antibody variable region binding affinity

US6849425B1 · kind B1 · utility

4Cited by

14References

30Claims

0Family size

Assignee

Ixsys, Inc. · US

Inventors

William D. Huse · Del Mar, US
Jeffry D. Watkins · Encinitas, US
Herren Wu · Boyds, US

Key dates

Filing date	Nov 4, 1999
Grant date	Feb 1, 2005
Priority date	—
Expiry date	Nov 4, 2019

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention provides a method of conferring donor CDR binding affinity onto an antibody acceptor variable region framework. The invention also provides a method of simultaneously grafting and optimizing the binding affinity of a variable region binding fragment. A method of optimizing the binding affinity of an antibody variable region is also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.