Aza-amino acid derivatives (factor Xa inhibitors 15)

US6849626B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Werner Mederski · Zwingenberg, DE
• Horst Juraszyk · Seeheim-Jugenheim, DE
• Dieter Dorsch · Ober-Ramstadt, DE
• Christos Tsaklakidis · Weinheim, DE
• Johannes Gleiltz · Darmstadt, DE
• Christopher Barnes · Bad Soden, DE

Key dates

• Filing date: Aug 21, 2001
• Grant date: Feb 1, 2005
• Expiry date: Aug 21, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to semicarbazides of the general formula I where R1, R2, R3, R4 and I have the meaning indicated in claim 1. The compounds of the formula I can be employed as pharmaceutical active compounds in human and veterinary medicine, in particular for the control and prevention of thromboembolic disorders such as thrombosis, mycocardial infarct, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.