6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

US6849627B2 · kind B2 · utility

Assignee

• The Procter & Gamble Company · US

Inventors

• Michael P. Clark · Maineville, US
• Matthew John Laufersweiler · Morrow, US
• Adam Golebiowski · Loveland, US
• Mark Sabat · Loveland, US
• Todd Andrew Brugel · Wilmington, US

Key dates

• Filing date: Mar 17, 2003
• Grant date: Feb 1, 2005
• Expiry date: May 30, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: wherein R1 is substituted aryl; R4 is substituted or unsubstituted aryl or heteroaryl.