Chromenone and chromanone derivatives as integrin inhibitors

US6849646B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Claus Fittschen · Fränkisch-Crumbach, DE
• Simon Goodman
• Joachim Marz · Groß-Gerau, DE
• Peter Raddatz · Darmstadt, DE
• Matthias Wiesner · Seeheim-Jugenheim, DE

Key dates

• Filing date: Oct 14, 1999
• Grant date: Feb 1, 2005
• Expiry date: Oct 14, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds having formula (I), wherein R1, R2, R3, R4, R5, R7, R8, R11, Z, m and n have the meaning cited in claim 1, and to the physiologically acceptable salts and solvates which can be used as integrin inhibitors, especially in the prophylaxis and treatment of circulatory diseases, in case of thrombosis, myocardial infarction, coronary heart diseases, arteriosclerosis, osteoporosis, pathologic processes caused or propagated by angiogenesis and in tumor therapy.