Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6849651B2 · kind B2 · utility
4Cited by
128References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 5, 2001 |
| Grant date | Feb 1, 2005 |
| Priority date | — |
| Expiry date | Jun 5, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.