Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents
US6849656B1 · kind B1 · utility
7Cited by
19References
39Claims
0Family size
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Key dates
| Filing date | Sep 15, 2000 |
| Grant date | Feb 1, 2005 |
| Priority date | — |
| Expiry date | Oct 15, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/5728
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as prodrugs, may well prove to be tumor selective vascular targeting and destruction chemotherapeutic agents or to have anti-angiogenesis activity resulting in the selective prevention and/or destruction of tumor cell vasculature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.