Process for preparing a trifluoroethoxy-substituted benzoic acid

US6849762B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Kai Fabian · Wilhelmsfeld, DE
• Steffen Enke · Hirschhorn, DE
• Herbert Tilly · Pfungstadt, DE

Key dates

• Filing date: May 23, 2001
• Grant date: Feb 1, 2005
• Expiry date: Aug 15, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/367
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method for the production of trifluoroethoxy-substituted benzoic acids, by reaction of a corresponding halogenated benzoic acid with trifluoroethanol in the solvent tetrahydrofuran, in the presence of a base and a copper salt, followed by an acidic work-up.