Production of ultrapure bismuth-213 for use in therapeutic nuclear medicine
US6852296B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 31, 2002 |
| Grant date | Feb 8, 2005 |
| Priority date | — |
| Expiry date | Jun 20, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S423/07
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A multicolumn selectivity inversion generator has been developed in which bismuth-213 is selectively extracted from an HCl solution of the actinium-225 parent (and its radiogenic descendents) by a primary separation column containing a separation medium containing a neutral oxygenated organophosphorus extractant. After rinsing with dilute HCl, the bismuth-213 is stripped with a buffered NaCl solution. The stripped solution is passed through a cation-exchange resin guard column that retains the actinium-225 and radium-225 contaminants while the bismuth-213 elutes. This generator method minimizes the unpredictable effects of radiation damage to the support material and permits the reliable production of bismuth-213 of high chemical and radionuclidic purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.