Recombinant baculovirus and use thereof in the production of monoclonal antibodies
US6852507B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 21, 1997 |
| Grant date | Feb 8, 2005 |
| Priority date | — |
| Expiry date | Nov 21, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Recombinant baculovirus used as an expression vector in the production of immunoglobulins with an insect cell. The invention is characterized by a first expression cassette comprising a first sequence coding for at least one portion of an immunoglobulin heavy chain, wherein the sequence is transcriptionally controlled by a first baculovirus promoter, and a second expression cassette comprising a second sequence coding for at least one portion of an immunoglobulin light chain, said second sequence being transcriptionally controlled by a second baculovirus promoter. The first and second promoters are two different promoters or derivatives of different promoters, the first and second promoters residing at different loci.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.