Nur-RE a response element which binds nur nuclear receptors and method of use therefor
US6852538B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 1997 |
| Grant date | Feb 8, 2005 |
| Priority date | — |
| Expiry date | Dec 12, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to intracellular receptors, and methods for the modulation of transcription using same. More particularly, the invention relates to the Nur family of nuclear receptors. In general aspects, the present invention relates to the idenfication of a physiologically relevant response element (RE) for Nur family members, an ER-10 element as well as to the idenfication of the type of protein-protein interactions of Nur family member, enabling their specific interaction with this RE-10 and tfeir modulation of transcription at physiologically relevant sites. The invention further relates to methods for modulating processes mediated by such nuclear receptors. In addition, the invention relates to oligonucleotide sequences that bind regulatory proteins that affect transcription, such as the Nur family of nuclear receptors, to DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, to methods of using same to provide for the controlled expression of heterologous genes, and for the detection and recovery of new regulatory proteins. The present invention further provides bioassays for the identification of compounds as poten…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.