Sustained release hydrophobic bioactive PLGA microspheres

US6855331B2 · kind B2 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Noelle Christine Vook · Schaumburg, US
• Elliott Jacob · Silver Spring, US
• Jean A. Setterstrom · Silver Spring, US
• John E. Van Hamont · Clarence, US
• William Vaughan · Silver Spring, US
• Ha Duong · Montclair, US

Key dates

• Filing date: Jun 10, 2002
• Grant date: Feb 15, 2005
• Expiry date: Aug 24, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1641
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A controlled release microcapsulate pharmaceutical formulation for burst-free, sustained, programmable release of hydrophobic bioactive agent over a duration from 24 hours to 100 days comprising: and a blend of end-capped uncapped biocompatible, biodegradable poly(lactide/glycolide).